Augmentin side Effects on ability to drive and use machines

No studies on the effects on the ability to drive and use machines have been performed. However, undesirable effects may occur (e.g. allergic reactions, dizziness, convulsions), which may influence the ability to drive and use machines.

Undesirable effects

The most commonly reported adverse drug reactions (ADRs) are diarrhoea, nausea and vomiting.

The ADRs derived from clinical studies and post-marketing surveillance with Augmentin, sorted by MedDRA System Organ Class are listed below.

The following terminologies have been used in order to classify the occurrence of undesirable effects.

Very common (≥1/10)

Common (≥1/100 to <1/10)

Uncommon (≥1/1,000 to <1/100)

Rare (≥1/10,000 to <1/1,000)

Very rare (<1/10,000)

Not known (cannot be estimated from the available data)

Infections and infestations
Mucocutaneous candidosis Common
Overgrowth of non-susceptible organisms Not known
Blood and lymphatic system disorders
Reversible leucopenia (including neutropenia) Rare
Thrombocytopenia Rare
Reversible agranulocytosis Not known
Haemolytic anaemia Not known
Prolongation of bleeding time and prothrombin time1 Not known
Immune system disorders10
Angioneurotic oedema Not known
Anaphylaxis Not known
Serum sickness-like syndrome Not known
Hypersensitivity vasculitis Not known
Nervous system disorders
Dizziness Uncommon
Headache Uncommon
Reversible hyperactivity Not known
Convulsions2 Not known
Aeseptic meningitis Not known
Gastrointestinal disorders
Diarrhoea Very common
Nausea3 Common
Vomiting Common
Indigestion Uncommon
Antibiotic-associated colitis4 Not known
Black hairy tongue Not known
Hepatobiliary disorders
Rises in AST and/or ALT5 Uncommon
Hepatitis6 Not known
Cholestatic jaundice6 Not known
Skin and subcutaneous tissue disorders7
Skin rash Uncommon
Pruritus Uncommon
Urticaria Uncommon
Erythema multiforme Rare
Stevens-Johnson syndrome Not known
Toxic epidermal necrolysis Not known
Bullous exfoliative-dermatitis Not known
Acute generalised exanthemous pustulosis (AGEP)9 Not known
Renal and urinary disorders
Interstitial nephritis Not known
Crystalluria8 Not known

3 Nausea is more often associated with higher oral doses. If gastrointestinal reactions are evident, they may be reduced by taking amoxicillin/clavulanic acid with a meal.

Including pseudomembranous colitis and haemorrhagic colitis (see section 4.4)

5 A moderate rise in AST and/or ALT has been noted in patients treated with beta-lactam class antibiotics, but the significance of these findings is unknown.

These events have been noted with other penicillins and cephalosporins (see section 4.4).

7 If any hypersensitivity dermatitis reaction occurs, treatment should be discontinued (see section 4.4).